Article
Genome-wide genetic association of complex traits in heterogeneous stock mice.
Nature genetics - 1 Aug 2006
Valdar William, Solberg Leah C, Gauguier Dominique, Burnett Stephanie, Klenerman Paul, Cookson William O, Taylor Martin S, Rawlins J Nicholas P, Mott Richard, Flint Jonathan
Abstract excerpt
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb....
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