Article
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
Journal of neuroscience research - 1 Jun 2008
Gandhi Payal N, Wang Xinglong, Zhu Xiongwei, Chen Shu G, Wilson-Delfosse Amy L
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the leading cause of genetically inherited Parkinson's disease (PD). Although this multidomain protein has been shown to have both GTPase and kinase activities through the Roc and MAPKKK domains, respectively, the protein-protein interactions and pathways involved in LRRK2-mediated signaling remain elusive. Utilizing a combination of protein pull-down...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- GTP Phosphohydrolases
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Microtubules
- Molecular Sequence Data
- Mutation
- NIH 3T3 Cells