Article
Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
Toxicologic pathology - 1 Jan 2006
McAllister Kimberly A, Houle Christopher D, Malphurs Jason, Ward Toni, Collins N Keith, Gersch William, Wharey Laura, Seely John C, Betz Laura, Bennett L Michelle, Wiseman Roger W, Davis Barbara J
Abstract excerpt
Mutations in both p53 and BRCA2 are commonly seen together in human tumors suggesting that the loss of both genes enhances tumor development. To elucidate this interaction in an animal model, mice lacking the carboxy terminal domain of Brca2 were crossed with p53 heterozygous mice. Females from this intercross were then irradiated with an acute dose of 5 Gy ionizing radiation at 5 weeks of age and compared to...
Topics
- Animals
- BRCA2 Protein
- Bone Neoplasms
- Carcinoma, Squamous Cell
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genetic Predisposition to Disease
- Genotype
- Germ-Line Mutation
- Mice
- Mice, Inbred C57BL