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Article

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors.

International journal of molecular sciences - 4 Jan 2022

Ueno Sayaka, Sudo Tamotsu, Hirasawa Akira

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) functions as a key initiator and coordinator of DNA damage and cellular stress responses. ATM signaling pathways contain many downstream targets that regulate multiple important cellular processes, including DNA damage repair, apoptosis, cell cycle arrest, oxidative sensing, and proliferation. Over the past few decades, associations between germline ATM pathogenic variants and...

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Source

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Identifiers

PMID: 35008949
DOI: 10.3390/ijms23010523
PMCID: PMC8745051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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