Article
Mutation patterns in cancer genomes.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009
Rubin Alan F, Green Phil
Abstract excerpt
Recent large-scale cancer sequencing studies have focused primarily on identifying cancer-associated genes, but as an important byproduct provide "passenger mutation" data that can potentially illuminate the mutational mechanisms at work in cancer cells. Here, we explore patterns of nucleotide substitution in several cancer types using published data. We first show that selection (negative or positive) has...
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