Reversibility of the malignant phenotype in monoclonal tumours in the mouse.

Abstract excerpt

Longterm goitrogen administration to rodents is well known to result in multiple proliferative lesions of the thyroid. The regression of these lesions on withdrawal of goitrogen has led to their neoplastic nature being questioned, and they have been regarded as 'nodules' rather than as true tumours. We have induced multiple thyroid lesions by the combined use of high dose radiation as a mutagen, together with...

Topics

• Animals
• Female
• Glucosephosphate Dehydrogenase
• Goiter
• Mice
• Phenotype
• Thyroid Neoplasms
• Thyrotropin
• Translocation, Genetic