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Article

Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1996

Derwahl M

Abstract excerpt

One of the most significant results of recent molecular thyroid research on the pathogenesis of nodular goiters may be the finding that not only thyroid adenomas but also many thyroid nodules are clonal in origin and thus are true benign tumors. Both clonal and polyclonal nodules may coexist within the same nodular goiter. Since clonal nodules may secondarily acquire a heterogeneous phenotype, they can become...

Topics

Adenoma
Clone Cells
GTP-Binding Proteins
Goiter, Nodular
Humans
Mutation
Oncogenes
Receptors, Thyrotropin
Thyroid Neoplasms
Thyroid Nodule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8980997
DOI: 10.1055/s-0029-1211697

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