Article
Pre-existing Thyroiditis Ameliorates Papillary Thyroid Cancer: Insights From a New Mouse Model.
Endocrinology - 1 Oct 2021
Pani Fabiana, Yasuda Yoshinori, Di Dalmazi Giulia, Chalan Paulina, Gabrielson Kathleen, Adamo Luigi, Sabini Elena, Mariotti Stefano, Caturegli Patrizio
Abstract excerpt
Papillary thyroid cancer (PTC) often co-occurs with Hashimoto's thyroiditis, an association that has long been reported in clinical studies yet remains controversial. Some studies, in fact, have suggested a protective effect of thyroiditis while others have not. We generated a mouse model where PTC and thyroiditis develop in a predictable manner, combining the oncogenic drive of the BRAFv600E mutation (inducible...
Topics
- Animals
- Antigens, CD19
- CD8-Positive T-Lymphocytes
- Crosses, Genetic
- Disease Models, Animal
- Female
- Genotype
- Hashimoto Disease
- Humans
- Immune System
- Male
- Mice
- Mice, Inbred NOD
- Mutation