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Article

Clonal composition of benign and malignant human thyroid tumors.

1 Jul 1990

Abstract excerpt

We determined clonality of thyroid tumors from female patients who had restriction fragment length polymorphisms (RFLP) in the X chromosome genes hypoxanthine phosphoribosyltransferase (HPRT) or phosphoglycerate kinase (PGK). We screened normal thyroid tissue from 59 female patients; of the informative cases 14 were heterozygous for a Bgl I site on PGK and 4 were heterozygous for a Bam HI site on HPRT. In...

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PMID: 1973172
DOI: 10.1172/jci114673

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