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Article

Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma.

Endocrinology - 1 Nov 2013

Shimamura Mika, Nakahara Mami, Orim Florence, Kurashige Tomomi, Mitsutake Norisato, Nakashima Masahiro, Kondo Shinji, Yamada Masanobu, Taguchi Ryo, Kimura Shioko, Nagayama Yuji

Abstract excerpt

The mutant BRAF (BRAF(V600E)) is the most common genetic alteration in papillary thyroid carcinomas (PTCs). The oncogenicity of this mutation has been shown by some genetically engineered mouse models. However, in these mice, BRAF(V600E) is expressed in all the thyroid cells from the fetal periods, and suppresses thyroid function, thereby leading to TSH elevation, which by itself promotes thyroid tumorigenesis....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23970782
DOI: 10.1210/en.2013-1174

Genes

BRAF
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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