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Article

Tumor Cell Plasticity and Stromal Microenvironment Distinguish Papillary and Follicular Growth Patterns in a Mouse Model of BRAFV600E-Induced Thyroid Cancer.

Cancer research communications - 1 Mar 2025

Schoultz Elin, Moccia Carmen, Liang Shawn, Johansson Ellen, Nilsson Mikael

Abstract excerpt

ABSTRACT: Differentiated thyroid cancer primarily classified by tumor histology comprises follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC), which represent distinct malignancies regarding the pattern of tumor spreading, responsiveness to radioiodine treatment, and clinical outcome. As FTC and PTC also differ genetically i.e., RAS mutations predominate in FTC whereas mutant BRAF is much...

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Source

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Identifiers

PMID: 39956582
DOI: 10.1158/2767-9764.CRC-24-0474
PMCID: PMC11885905

Genes

BRAF

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