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Article

Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.

Annals of neurology - 1 Apr 2004

Enzinger Christian, Ropele Stefan, Smith Stephen, Strasser-Fuchs Siegrid, Poltrum Birgit, Schmidt Helena, Matthews Paul M, Fazekas Franz

Abstract excerpt

Apolipoprotein E (APOE)-epsilon4 has been associated with an unfavorable course of multiple sclerosis (MS). The mechanisms responsible for this are unclear, although cross-sectional MRI demonstrated a higher extent of "black holes" (BHs) in such patients. Here, we have studied the impact of the APOE genotype on both the longitudinal evolution of focal (BH ratio) and global (brain volume change [BVC]) brain tissue...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15048896
DOI: 10.1002/ana.20027

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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