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Article

Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.

Annals of neurology - 1 Apr 2004

Enzinger Christian, Ropele Stefan, Smith Stephen, Strasser-Fuchs Siegrid, Poltrum Birgit, Schmidt Helena, Matthews Paul M, Fazekas Franz

Abstract excerpt

Apolipoprotein E (APOE)-epsilon4 has been associated with an unfavorable course of multiple sclerosis (MS). The mechanisms responsible for this are unclear, although cross-sectional MRI demonstrated a higher extent of "black holes" (BHs) in such patients. Here, we have studied the impact of the A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15048896
DOI: 10.1002/ana.20027

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15048896-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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