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Article

Influence of apolipoprotein E epsilon4 genotype on brain tissue integrity in relapsing-remitting multiple sclerosis.

Archives of neurology - 1 Apr 2004

De Stefano Nicola, Bartolozzi Maria Letizia, Nacmias Benedetta, Zipoli Valentina, Mortilla Marzia, Guidi Leonello, Siracusa Gianfranco, Sorbi Sandro, Federico Antonio, Amato Maria Pia

Abstract excerpt

BACKGROUND: Recent clinical and imaging studies have raised the hypothesis that patients with multiple sclerosis (MS) and the apolipoprotein E (ApoE) epsilon4 allele may have a more severe disease course than those without the ApoE epsilon4 allele. This seems to be related to more extensive tissue destruction and less efficient neuronal maintenance and repair in ApoE epsilon4 carriers. OBJECTIVE: To evaluate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15096402
DOI: 10.1001/archneur.61.4.536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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