Article
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.
Science (New York, N.Y.) - 24 Feb 1995
Kirchgessner C U, Patil C K, Evans J W, Cuomo C A, Fried L M, Carter T, Oettinger M A, Brown J M
Abstract excerpt
Severe combined immunodeficient (SCID) mice are deficient in a recombination process utilized in both DNA double-strand break repair and in V(D)J recombination. The phenotype of these mice involves both cellular hypersensitivity to ionizing radiation and a lack of B and T cell immunity. The catalytic subunit of DNA-dependent protein kinase, p350, was identified as a strong candidate for the murine gene SCID. Both...
Topics
- Animals
- Base Sequence
- Cell Line
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Cloning, Molecular
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Gamma Rays
- Genetic Complementation Test