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Article

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.

Science (New York, N.Y.) - 24 Feb 1995

Kirchgessner C U, Patil C K, Evans J W, Cuomo C A, Fried L M, Carter T, Oettinger M A, Brown J M

Abstract excerpt

Severe combined immunodeficient (SCID) mice are deficient in a recombination process utilized in both DNA double-strand break repair and in V(D)J recombination. The phenotype of these mice involves both cellular hypersensitivity to ionizing radiation and a lack of B and T cell immunity. The catalytic subunit of DNA-dependent protein kinase, p350, was identified as a strong candidate for the murine gene SCID. Both...

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Identifiers

PMID: 7855601
DOI: 10.1126/science.7855601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.PMID 7855601Read ↗

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.Semantic proximity Read ↗

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.Semantic proximity Read ↗

A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair DeficiencySemantic proximity Read ↗

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.Semantic proximity Read ↗

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.Semantic proximity Read ↗

Immune deficiency in SCID mice.Semantic proximity Read ↗

The SCID mouse mutant: definition, characterization, and potential uses.Semantic proximity Read ↗

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeSemantic proximity Read ↗

Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres.Semantic proximity Read ↗

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency miceSemantic proximity Read ↗

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.Semantic proximity Read ↗

Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene.Semantic proximity Read ↗

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