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Article

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2003

Cook Adam J L, Oganesian Liana, Harumal Pearly, Basten Antony, Brink Robert, Jolly Christopher J

Abstract excerpt

Deoxyribonucleic acid double-stranded breaks act as intermediates in Ig V(D)J recombination and probably perform a similar function in class switch recombination between IgH C genes. In SCID mice, V(D)J recombination is blocked because the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein is defective. We show in this study that switching to all isotypes examined was detectable when the SCID...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14662857
DOI: 10.4049/jimmunol.171.12.6556

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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