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Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function

18 Nov 2022

Abstract excerpt

Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the treatment of female cancer patients with BRCA mutations, including younger patients. However, the impact of PARPi on ovarian function remains a considerable problem in clinical practice. In this review article, we summarize the current...

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PMID: 36410122
DOI: 10.1016/j.biopha.2022.114028

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