p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

doi:10.1073/pnas.92.8.3224

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Article

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995

Ishizaka Y, Chernov M V, Burns C M, Stark G R

Abstract excerpt

The rat cell line REF52 is not permissive for gene amplification. Simian virus 40 tumor (T) antigen converts these cells to a permissive state, as do dominant negative mutants of p53, suggesting that the effect of T antigen is due mainly to its ability to bind to p53. To manipulate permissivity,...

Topics

Animals
Antigens, Viral, Tumor
Aspartate Carbamoyltransferase
Aspartic Acid
Carbamyl Phosphate
Cell Cycle
Cell Line
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA Damage
DNA Replication
Dihydroorotase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance

Gene Amplification

Hot Temperature

In Situ Hybridization, Fluorescence

Ligases

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7724543
DOI: 10.1073/pnas.92.8.3224
PMCID: PMC42138

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7724543-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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