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Article

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995

Ishizaka Y, Chernov M V, Burns C M, Stark G R

Abstract excerpt

The rat cell line REF52 is not permissive for gene amplification. Simian virus 40 tumor (T) antigen converts these cells to a permissive state, as do dominant negative mutants of p53, suggesting that the effect of T antigen is due mainly to its ability to bind to p53. To manipulate permissivity, we introduced a temperature-sensitive mutant of T antigen (tsA58) into REF52 cells and selected for resistance to...

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Identifiers

PMID: 7724543
DOI: 10.1073/pnas.92.8.3224
PMCID: PMC42138

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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