Article
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.
PloS one - 24 Nov 2009
Guo Jianhui, Cagatay Tolga, Zhou Guangjin, Chan Chih-Chiang, Blythe Shelby, Suyama Kaye, Zheng Li, Pan Kaifeng, Qian Chiping, Hamelin Richard, Thibodeau Stephen N, Klein Peter S, Wharton Keith A, Liu Wanguo
Abstract excerpt
BACKGROUND: Mutation of Wnt signal antagonists Apc or Axin activates beta-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The phenotype of apc or axin mutation in the fruit fly Drosophila melanogaster is strikingly similar to that caused by mutation i...
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