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Article

Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma

2 Apr 2008

Abstract excerpt

Constitutive activation of the Wnt pathway plays a key role in the development of colorectal cancer and has also been implicated in the pathogenesis of other malignancies. Deregulation of Wnt signaling mainly occurs through genetic alterations of APC, the beta-catenin gene (CTNNB1), AXIN1 and AXIN2, leading to stabilization of beta-catenin. Physiologically, AXIN2 is transcriptionally induced on Wnt signaling...

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PMID: 18384130
DOI: 10.1002/gcc.20567

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