Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Naked cuticle targets dishevelled to antagonize Wnt signal transduction.

Genes & development - 15 Mar 2001

Rousset R, Mack J A, Wharton K A, Axelrod J D, Cadigan K M, Fish M P, Nusse R, Scott M P

Abstract excerpt

In Drosophila embryos the protein Naked cuticle (Nkd) limits the effects of the Wnt signal Wingless (Wg) during early segmentation. nkd loss of function results in segment polarity defects and embryonic death, but how nkd affects Wnt signaling is unknown. Using ectopic expression, we find that Nkd affects, in a cell-autonomous manner, a transduction step between the Wnt signaling components Dishevelled (Dsh) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Armadillo Domain Proteins
Share to Dishevelled Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Insect Proteins

Share to Photoreceptor Cells, Invertebrate

Share to Precipitin Tests

Share to Two-Hybrid System Techniques

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11274052
DOI: 10.1101/gad.869201
PMCID: PMC312650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Naked cuticle targets dishevelled to antagonize Wnt signal transduction.PMID 11274052Read ↗

An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.Semantic proximity Read ↗

Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.Semantic proximity Read ↗

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.Semantic proximity Read ↗

Components of wingless signalling in Drosophila.Semantic proximity Read ↗

Wingful, an extracellular feedback inhibitor of Wingless.Semantic proximity Read ↗

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Semantic proximity Read ↗

Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos.Semantic proximity Read ↗

Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.Semantic proximity Read ↗

Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing.Semantic proximity Read ↗

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.Semantic proximity Read ↗

Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled.Semantic proximity Read ↗

A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.