Article
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2009
Rodilla Verónica, Villanueva Alberto, Obrador-Hevia Antonia, Robert-Moreno Alex, Fernández-Majada Vanessa, Grilli Andrea, López-Bigas Nuria, Bellora Nicolás, Albà M Mar, Torres Ferran, Duñach Mireia, Sanjuan Xavier, Gonzalez Sara, Gridley Thomas, Capella Gabriel, Bigas Anna, Espinosa Lluís
Abstract excerpt
Notch has been linked to beta-catenin-dependent tumorigenesis; however, the mechanisms leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not yet understood. By microarray analysis, we have identified a group of genes downstream of Wnt/beta-catenin (down-regulated when blocking Wnt/beta-catenin) that are directly regulated by Notch (repressed by gamma-secretase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.