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Elevated expression of <i>axin2</i> and <i>hnkd</i> mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

18 Dec 2001

Abstract excerpt

Genetic studies have identified mutations in key regulators of the Wnt/beta-catenin pathway in a variety of cancers, most frequently in colon cancers. However, whether the pathway is activated in clinical cancer samples is not easily determined, and therefore it is useful to find markers that could be surrogates to show activation of the Wnt/beta-catenin pathway. Gene expression profiles were analyzed in SW620, a...

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PMID: 11752446
DOI: 10.1073/pnas.261574498

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Elevated expression of <i>axin2</i> and <i>hnkd</i> mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumorsPMID 11752446Read ↗

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