Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterodimeric capping protein is required for stereocilia length and width regulation.

The Journal of cell biology - 6 Nov 2017

Avenarius Matthew R, Krey Jocelyn F, Dumont Rachel A, Morgan Clive P, Benson Connor B, Vijayakumar Sarath, Cunningham Christopher L, Scheffer Deborah I, Corey David P, Müller Ulrich, Jones Sherri M, Barr-Gillespie Peter G

Abstract excerpt

Control of the dimensions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated activity of many proteins. Each of these actin structures relies on heterodimeric capping protein (CAPZ), which blocks actin polymerization at barbed ends. Because dimension control of the inner ear's stereocilia is particularly precise, we studied the CAPZB subunit in hair cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Auditory Threshold
Share to Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chick Embryo

Share to Evoked Potentials, Auditory, Brain Stem

Share to Hair Cells, Auditory

Share to Otoacoustic Emissions, Spontaneous

Share to Vestibule, Labyrinth

Source

Open in PubMed Open full text

Identifiers

PMID: 28899994
DOI: 10.1083/jcb.201704171
PMCID: PMC5674897

Genes

CAPZB
TWF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterodimeric capping protein is required for stereocilia length and width regulation.PMID 28899994Read ↗

Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.Semantic proximity Read ↗

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia MaintenanceSemantic proximity Read ↗

Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†.Semantic proximity Read ↗

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase patternSemantic proximity Read ↗

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.Semantic proximity Read ↗

Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.Semantic proximity Read ↗

β-Actin and fascin-2 cooperate to maintain stereocilia length.Semantic proximity Read ↗

Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochleaSemantic proximity Read ↗

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Semantic proximity Read ↗

A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil.Semantic proximity Read ↗

Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.Semantic proximity Read ↗

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.