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Genotyping of UGT1A180 as an Alternative to UGT1A128 Genotyping in Spain

29 Sept 2022

Abstract excerpt

Background: The variant rs34983651 (UGT1A1*28) and its genotyping are used to prevent irinotecan-induced toxicity. Several variants are in close linkage disequilibrium. Our objective was to evaluate the potential correlation of genotyping UGT1A1*80 instead of UGT1A1*28 in different populations. Methods: We studied SNPs in linkage disequilibrium with UGT1A1*28 in several populations and selected rs887829 to...

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PMID: 36297516
DOI: 10.3390/pharmaceutics14102082

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