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Diversity of oncopharmacogenetic profile within Spanish population.

Pharmacogenetics and genomics - 1 Jul 2024

Ferrer Bolufer Irene, Galiana Vallés Ximo, Izquierdo Álvarez Silvia, Serrano Mira Ana, Guzmán Luján Carola, Safont Aguilera María José, González Tarancón Ricardo, Bolaños Naranjo Matilde, Carrasco Salas Pilar, Santamaría González María, Rodríguez-López Raquel

Abstract excerpt

Consensus guidelines for genotype-guided fluoropyrimidine dosing based on variation in the dihydropyrimidine dehydrogenase (DPYD) gene before treatment have been firmly established. The prior pharmacogenetic report avoids the serious toxicity that inevitably occurred in a non-negligible percentage of the treated patients. The precise description of the allelic distribution of the variants of interest in our...

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PMID: 38488402
DOI: 10.1097/FPC.0000000000000530

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