Article
An analysis of synthetic peptide restriction by HLA-DR alleles in T cells from human subjects, naturally sensitized by Streptococcus mutans.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1991
Childerstone A, Altmann D, Haron J A, Wilkinson D, Trowsdale J, Lehner T
Abstract excerpt
T cells from most human subjects show significant in vitro proliferative responses to a 185-kDa surface Ag from Streptococcus mutans as well as to synthetic peptides derived from the sequence of a Mr 3800 streptococcal Ag. T cells from subjects expressing each of the alleles from DR1 to DR7 respo...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Bacterial Proteins
- HLA Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class I
- Humans
- L Cells
- Lymphocyte Activation
- Molecular Sequence Data
- Peptide Fragments
- Streptococcus mutans
- T-Lymphocytes
- Transfection