Article
Role of peptide antigen for induction of inhibitory antibodies to Streptococcus mutans in human oral cavity.
Clinical and experimental immunology - 1 Aug 2004
Tsuha Y, Hanada N, Asano T, Abei T, Yamaguchi S, Salam M A, Nakao R, Takeuchi H, Kurosaki N, Senpuku H
Abstract excerpt
The alanine-rich repeating region (A-region) in the surface protein antigen (PAc) of Streptococcus mutans has received much attention as an antigenic component for vaccines against dental caries. The PAc (residue 361-386) peptide in the A-region possesses a multiple binding motif (L- -V-K- -A) to various HLA-DR molecules and a B-cell core epitope (- Y- - -L- -Y- - - -) that recognizes the inhibiting antibody to...
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