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Article

Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.

The Journal of clinical investigation - 15 Jul 1997

Uitterlinden A G, Burger H, Huang Q, Odding E, Duijn C M, Hofman A, Birkenhäger J C, van Leeuwen J P, Pols H A

Abstract excerpt

Osteoporosis and osteoarthritis are age-related disorders of the skeleton with genetic components. Low bone density is a risk factor for osteoporotic fracture while osteoarthritis is associated with increased bone density. The 1,25-dihydroxyvitamin D3 receptor (VDR) gene locus was previously found to be associated with bone density. We therefore studied the relationship between radiographic osteoarthritis at the...

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Identifiers

PMID: 9218501
DOI: 10.1172/JCI119530
PMCID: PMC508187

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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