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Article

Profiling Cancer-Associated Fibroblasts in Melanoma

6 Jul 2021

Abstract excerpt

Solid tumors are complex systems characterized by dynamic interactions between neoplastic cells, non-tumoral cells, and extracellular components. Among all the stromal cells that populate tumor microenvironment, fibroblasts are the most abundant elements and are critically involved in disease progression. Cancer-associated fibroblasts (CAFs) have pleiotropic functions in tumor growth and extracellular matrix...

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PMID: 34298873
DOI: 10.3390/ijms22147255

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