Article
Interactions of melanocytes and melanoma cells with the microenvironment.
Pigment cell research - 1 Apr 1994
Herlyn M, Shih I M
Abstract excerpt
Normal or malignant melanocytes interact with the microenvironment through the release of soluble factors from cells and through direct cell-cell contact. Melanoma cells produce a large number of different growth factors and cytokines that affect angiogenesis, stroma formation, motility, and the inflammatory and immune response. Most of the angiogenic growth factors produced by melanoma cells are also mitogenic...
Topics
- Cell Communication
- Growth Substances
- Humans
- Keratinocytes
- Melanocytes
- Melanoma
- Models, Biological
- Phenotype