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Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets.

Cell reports - 19 Sept 2017

Galland Sabine, Vuille Joanna, Martin Patricia, Letovanec Igor, Caignard Anne, Fregni Giulia, Stamenkovic Ivan

Abstract excerpt

Mesenchymal stem cells (MSCs) display pleiotropic functions, which include secretion of soluble factors with immunosuppressive activity implicated in cancer progression. We compared the immunomodulatory effects on natural killer (NK) cells of paired intratumor (T)- and adjacent non-tumor tissue (N)-derived MSCs from patients with squamous cell lung carcinoma (SCC). We observed that T-MSCs were more strongly...

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Identifiers

PMID: 28930684
DOI: 10.1016/j.celrep.2017.08.089

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MSC

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