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Article

Positive crosstalk between ERK and p38 in melanoma stimulates migration and in vivo proliferation.

Pigment cell & melanoma research - 1 Feb 2009

Estrada Yeriel, Dong Jianli, Ossowski Liliana

Abstract excerpt

Melanoma is one of the most therapy-resistant cancers. Activating mutations in BRAF and NRAS are the source of extracellular signal regulated protein kinase (ERK) pathway activation. We show that melanoma cell lines, originating in different metastatic sites, with BRAF or NRAS mutations, in addition to active mitogen activated protein kinase (MAPK)-ERK, also have highly activated stress activated protein kinase...

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Source

Identifiers

PMID: 18983537
DOI: 10.1111/j.1755-148X.2008.00520.x

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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