Article
Human monoclonal HLA antibodies reveal interspecies crossreactive swine MHC class I epitopes relevant for xenotransplantation.
Molecular immunology - 1 Jan 2010
Mulder Arend, Kardol Marrie J, Arn J Scott, Eijsink Chantal, Franke Marry E I, Schreuder Geziena M T, Haasnoot Geert W, Doxiadis Ilias I N, Sachs David H, Smith Douglas M, Claas Frans H J
Abstract excerpt
Crossreactivity of anti-HLA antibodies with SLA alleles may limit the use of pig xenografts in some highly sensitized patients. An understanding of the molecular basis for this crossreactivity may allow better selection of xenograft donors. We have tested 68 human monoclonal HLA class I antibodies (mAbs) for reactivity with pig lymphocytes from SLA defined pigs and found nine to be crossreactive. Eight of nine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.