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The desirable donor pig to eliminate all xenoreactive antigens

2 Mar 2019

Abstract excerpt

The humoral barrier has been the limiting factor in moving xenotransplantation towards the clinic. Improvements in somatic cell nuclear transfer and genome editing, particularly CRISPR-Cas9, have made it possible to create pigs with multiple glycan xenoantigen deletions for the purposes of reducing xenoreactive antibody binding to the xenografted organ. Recent studies have also considered the aetiology and...

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PMID: 30825348
DOI: 10.1111/xen.12504

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