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Article

Does human leukocyte antigens sensitization matter for xenotransplantation?

1 May 2018

Abstract excerpt

The major histocompatibility complex class I and class II human leukocyte antigens (HLA) play a central role in adaptive immunity but are also the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, reduced allograft survival and often experience prolonged waiting times prior...

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PMID: 29913037
DOI: 10.1111/xen.12411

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