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Article

Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs.

Transplantation - 1 Mar 2016

Wang Zheng-Yu, Li Ping, Butler James R, Blankenship Ross L, Downey Susan M, Montgomery Jessica B, Nagai Shunji, Estrada Jose L, Tector Matthew F, Tector A Joseph

Abstract excerpt

BACKGROUND: Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-α(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human antibody binding to porcine peripheral blood mononuclear cells. It is important to examine rejection pathways at an organ-specific level. The object of this study is to evaluate the human preformed antibody reactivity against DKO renal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26906938
DOI: 10.1097/TP.0000000000001070

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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