Article
Polymorphism in the human anti-pig natural antibody repertoire: implications for antigen-specific immunoadsorption.
Transplantation - 15 Sept 1998
McKane W, Lee J, Preston R, Hacking A, Simpson P, Lynds S, Goldberg L, Cairns T, Taube D
Abstract excerpt
BACKGROUND: Anti-Galalpha1-3Gal antibodies cause hyperacute rejection (HAR) in pig-to-primate xenotransplantation. Long-term graft survival has not been achieved despite abrogation of HAR using transgenic pigs. IgG and IgM anti-Galalpha1-3Gal also play a role in the events following abrogation of...
Topics
- Animals
- Antibodies, Heterophile
- Antibody Diversity
- Disaccharides
- Epitopes
- Humans
- Immunoglobulin G
- Immunosorbents
- Phenotype
- Polymorphism, Genetic
- Swine
- Transplantation, Heterologous