Article
Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1995
Yamada K, Sachs D H, DerSimonian H
Abstract excerpt
Partially inbred, MHC homozygous miniature swine have been used to study the nature of the human xenogeneic cellular immune response to swine Ags in vitro. Human T cells responded to xeno-MHC Ags in MLR at least as well as they did to allo-MHC Ags and appeared to share similar requirements for AP...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Clone Cells
- Cytotoxicity Tests, Immunologic
- Epitope Mapping
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Humans
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Swine
- Swine, Miniature
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic