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Article

Detection of loss of heterozygosity in formalin-fixed paraffin-embedded tumor specimens by the polymerase chain reaction.

The American journal of pathology - 1 Feb 1991

Bianchi A B, Navone N M, Conti C J

Abstract excerpt

A polymerase chain reaction-based procedure was used for the detection of DNA length polymorphisms generated by naturally occurring genetic deletions or insertions of known sequence. This method consists of a simple one-step assay that does not require any restriction enzyme analysis or Southern...

Topics

Alleles
Amino Acid Sequence
Animals
Chromosome Mapping
Formaldehyde
Heterozygote
Histological Techniques
Mice
Molecular Sequence Data
Polymerase Chain Reaction
Skin Neoplasms
Tumor Cells, Cultured

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Identifiers

PMID: 1992758
PMCID: PMC1886207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1992758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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