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Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.

Molecular carcinogenesis - 1 Oct 2000

Kleymenova E, Muga S, Fischer S, Walker C L

Abstract excerpt

Denaturing high-performance liquid chromatography (DHPLC)-based DNA fragment analysis is a high-throughput technology that can be used to obtain information on both genetic alterations and gene expression. By using different approaches based on polymerase chain reaction, this technique can be used to determine loss or gain of an allele, to quantitate the amount of RNA expressed, and to detect a single nucleotide...

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PMID: 11074601

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