PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue.

doi:10.1038/bjc.1993.333

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Article

PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue.

British journal of cancer - 1 Aug 1993

Gruis N A, Abeln E C, Bardoel A F, Devilee P, Frants R R, Cornelisse C J

Abstract excerpt

PCR-based microsatellite polymorphisms have proved their power in genetic linkage analysis and other identification methods, due to their high information content and even distribution over the chromosomes. In the present study we applied microsatellite polymorphisms to detect loss of heterozygosity in fresh (snap-frozen) and in archival ovarian tumour tissue. Clear allele losses were found in fresh and paraffin...

Topics

Adenocarcinoma
Alleles
Base Sequence
Blotting, Southern
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 17
DNA, Neoplasm
DNA, Satellite
Endometrial Neoplasms
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Leukocytes

Molecular Sequence Data

Oligodeoxyribonucleotides

Ovarian Neoplasms

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8102243
DOI: 10.1038/bjc.1993.333
PMCID: PMC1968571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8102243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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