Article
An assay for loss of heterozygosity in vivo at the Dlb-1 locus.
Mutagenesis - 1 Sept 1995
Vomiero-Highton G, Heddle J A
Abstract excerpt
Loss of heterozygosity (LOH) is a frequent event in many tumours, resulting in the loss of tumour suppressor genes and ultimately magnifying the number of cells with a mutant phenotype. We have used the Dlb-1 locus as a simple quantitative assay for LOH in vivo. Mutations of the dominant Dlb-1b a...
Topics
- Alleles
- Animals
- Crosses, Genetic
- Ethylnitrosourea
- Gene Deletion
- Genes, Recessive
- Heterozygote
- Intestine, Small
- Lectins
- Mice
- Mice, Inbred C57BL
- Mutagenicity Tests
- Mutagens
- Plant Lectins
- Staining and Labeling