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Article

Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations.

Mutagenesis - 1 Sept 1994

Liechty M C, Hassanpour Z, Hozier J C, Clive D

Abstract excerpt

The mouse lymphoma (L5178Y tk+/- 3.7.2C) in vitro mutagenesis assay can measure the genotoxic effects of a wide variety of chemical agents by inactivation of a single functional thymidine kinase (tk-1) gene. We have previously demonstrated, using cytogenetic and molecular techniques, that the typ...

Topics

Animals
Chromosome Mapping
DNA, Satellite
Genetic Markers
Heterozygote
Leukemia L5178
Mice
Minisatellite Repeats
Mutagenicity Tests
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Thymidine Kinase

Source

Identifiers

PMID: 7837976
DOI: 10.1093/mutage/9.5.423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7837976-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations.PMID 7837976Read ↗

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Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.Semantic proximity Read ↗

Sequence analysis of tka(-)-1 and tkb(+)-1 alleles in L5178Y tk+/- mouse-lymphoma cells and spontaneous tk-/- mutants.Semantic proximity Read ↗

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Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers.Semantic proximity Read ↗

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Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.Semantic proximity Read ↗

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