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Article

Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2012

Iwata Yasunori, Boström Elisabeth A, Menke Julia, Rabacal Whitney A, Morel Laurence, Wada Takashi, Kelley Vicki R

Abstract excerpt

CSF-1, required for macrophage (Mø) survival, proliferation, and activation, is upregulated in the tubular epithelial cells (TECs) during kidney inflammation. CSF-1 mediates Mø-dependent destruction in lupus-susceptible mice with nephritis and, paradoxically, Mø-dependent renal repair in lupus-re...

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Identifiers

PMID: 22467656
DOI: 10.4049/jimmunol.1102154
PMCID: PMC3340928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22467656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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