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Article

HMGCR rs17671591 SNP Determines Lower Plasma LDL-C after Atorvastatin Therapy in Chilean Individuals.

Basic & clinical pharmacology & toxicology - 1 Apr 2016

Cuevas Alejandro, Fernández César, Ferrada Luis, Zambrano Tomás, Rosales Alexy, Saavedra Nicolás, Salazar Luis A

Abstract excerpt

Lipid-lowering response to statin therapy shows large interindividual variability. At a genome-wide significance level, single nucleotide polymorphisms (SNPs) in PCSK9 and HMGCR have been implicated in this differential response. However, the influence of these variants is uncertain in the Chilean population. Hence, we aimed to evaluate the contribution of PCSK9 rs7552841 and HMGCR rs17671591 SNPs as genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anticholesteremic Agents
Share to Atorvastatin
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Share to Cholesterol, LDL
Share to Hydroxymethylglutaryl CoA Reductases
Share to Hypercholesterolemia
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Source

Identifiers

PMID: 26408409
DOI: 10.1111/bcpt.12493

Genes

HMGCR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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