Article
HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins.
BMC cardiovascular disorders - 24 Jun 2023
Li Jiawen, Tang Xiaofang, Xu Jingjing, Liu Ru, Jiang Lin, Xu Lianjun, Tian Jian, Feng Xinxing, Wu Yajie, Zhang Yin, Wang Dong, Sun Kai, Xu Bo, Zhao Wei, Hui Rutai, Gao Runlin, Song Lei, Yuan Jinqing, Zhao Xueyan
Abstract excerpt
BACKGROUND: To investigate the association of HMGCR and NPC1L1 gene polymorphisms with residual cholesterol risk (RCR) in patients with premature triple-vessel disease (PTVD). METHODS: Three SNPs within HMGCR including rs12916, rs2303151, and rs4629571, and four SNPs within NPC1L1 including rs11763759, rs4720470, , and were genotyped. RCR was defined as achieved low-density lipoprotein...