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Article

Domain-specific response of imprinted genes to reduced DNMT1.

Molecular and cellular biology - 1 Aug 2010

Weaver Jamie R, Sarkisian Garnik, Krapp Christopher, Mager Jesse, Mann Mellissa R W, Bartolomei Marisa S

Abstract excerpt

Imprinted genes are expressed in a monoallelic, parent-of-origin-specific manner. Clusters of imprinted genes are regulated by imprinting control regions (ICRs) characterized by DNA methylation of one allele. This methylation is critical for imprinting; a reduction in the DNA methyltransferase DNMT1 causes a widespread loss of imprinting. To better understand the role of DNA methylation in the regulation of...

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Source

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Identifiers

PMID: 20547750
DOI: 10.1128/MCB.01278-09
PMCID: PMC2916450

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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