Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effective Relief of Neuropathic Pain by Adeno-Associated Virus-Mediated Expression of a Small Hairpin Rna against GTP Cyclohydrolase 1

1 Jan 2009

Abstract excerpt

BACKGROUND: Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved in the development and persistency of pain symptoms. We thus hypothesize that neuropathic pain may be attenuated by down-regulation of GCH1 expression, and propose a gene silencing system for this purpose. RESULTS: To interrupt GCH1 synthesis, we designed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Pain Mechanisms and Treatments
Share to Spine and Intervertebral Disc Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19922668
DOI: 10.1186/1744-8069-5-67

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effective Relief of Neuropathic Pain by Adeno-Associated Virus-Mediated Expression of a Small Hairpin Rna against GTP Cyclohydrolase 1PMID 19922668Read ↗

Long-lasting Analgesia via Targeted <i>in vivo</i> Epigenetic Repression of Nav1.7Semantic proximity Read ↗

Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerveSemantic proximity Read ↗

Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virusSemantic proximity Read ↗

Lentiviral Gene Transfer into the Dorsal Root Ganglion of Adult RatsSemantic proximity Read ↗

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.Semantic proximity Read ↗

Herpes Vector–mediated Gene Transfer in the Treatment of Chronic PainSemantic proximity Read ↗

Evidence of a role for GTP cyclohydrolase-1 in visceral pain.Semantic proximity Read ↗

Polymorphisms in the GTP cyclohydrolase gene ( GCH1 ) are associated with ratings of capsaicin painSemantic proximity Read ↗

Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in miceSemantic proximity Read ↗

GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases.Semantic proximity Read ↗

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.Semantic proximity Read ↗

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic painSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.