Article

Long-lasting Analgesia via Targeted <i>in vivo</i> Epigenetic Repression of Nav1.7

2019-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Current treatments for chronic pain rely largely on opioids despite their unwanted side effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to nociceptive processing, with the voltage-gated sodium channel, Na V 1.7 (SCN9A), being perhaps the most promising candidate for analgesic drug development. Specifically, a hereditary loss-of-function mutation in N...

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Literature Corpus work: 121f1aec-e0c6-58cd-8af0-013b6d25b053
DOI: 10.1101/711812

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