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Article

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

European journal of pain (London, England) - 1 Nov 2008

Tegeder Irmgard, Adolph Jan, Schmidt Helmut, Woolf Clifford J, Geisslinger Gerd, Lötsch Jörn

Abstract excerpt

BACKGROUND: Carriers of a particular haplotype of the GTP cyclohydrolase gene (GCH1) had less pain after surgery for chronic lumbar radiculopathy and a decreased sensitivity to some experimental mechanical pain stimuli. Ex-vivo, GCH1 upregulation and BH4 production after forskolin stimulation were reduced, while baseline BH4 concentrations were not affected. This suggested that the haplotype may mainly exert its...

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Source

Identifiers

PMID: 18374612
DOI: 10.1016/j.ejpain.2008.02.004

Genes

GCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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